发给老马备查:
0 e8 \( p/ u% B5 \) j2 ]* U/ m8 v' H滴水察海(69304838) 15:23:23
# |" [8 T7 |8 ^1 y, K老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
+ m2 U; ^- |* a8 c, O吉非替尼和S-1连用的依据
% C5 D" d: y6 d* |Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.: g7 p, A" G( ^' \: q- A
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达3 I& N( V" p* u. N) C. g" M
这样是不是推理出,耐药后,可以用S-1和培美了?
. c- Z- B3 k- ^结论:- Z- a+ u' k9 @! v k9 N
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |